OG-L002 1357302-64-7

OGL002
分子式：C15H15NO   分子量：225.29
 
產(chǎn)品描述
OG-L002是有效的，特異性LSD1抑制劑，IC50為20 nM, 比作用于MAO-B和MAO-A選擇性分別高36和69倍。
靶點(diǎn)
LSD1
         
IC50
20 nM
         
體外研究
OG-L002 potently inhibits HSV IE gene expression in both HeLa and HFF cells with IC50 of ~10 μM and ~3 μM , respectively. OG-L002 treatment (50 μM ) results in the reduced production of progeny virus with no significant toxicity in HeLa or HFF cells. OG-L002 (50 μM ) increases the levels of repressive chromatin on viral IE gene promoters. In addition, OG-L002 also represses the expression of hCMV IE genes and adenovirus E1A gene.
體內(nèi)研究
OG-L002 (6 to 40 mg/kg) represses HSV primary infection in a dose-dependent manner in a mouse model. Moreover, OG-L002 also represses HSV reactivation from latency in a mouse ganglion explant model.
溶解性
DMSO 45 mg/mL，水 <1 mg/mL，乙醇 19 mg/mL
穩(wěn)定性
2年 -20°C粉狀，6月-80°C溶于DMSO