Kenpaullone  142273-20-9

Kenpaullone
分子式：C16H11BrN2O   分子量：327.17
 
產(chǎn)品描述
Kenpaullone是一種有效的CDK1/cyclin B、GSK-3β抑制劑，IC50分別為0.4、0.23μM
靶點(diǎn)
 CDK1/cyclin B
 GSK-3β
       
IC50
 0.4μM
 0.23μM
       
生物活性
Potent inhibitor of CDK1/cyclin B and GSK-3β (IC50 values are 0.4 and 0.23 μM respectively). Also inhibits CDK2/cyclin A, CDK2/cyclin E and CDK5/cyclin/p35 (IC50 values are 0.68, 7.5 and 0.85 μM respectively). Selective over c-src (IC50 = 15 μM), casein kinase 2 (IC50 = 20 μM), ERK1 (IC50 = 20 μM), ERK2 (IC50 = 9 μM) and a range of other protein kinases (IC50 values > 35 μM). Generates induced pluripotent stem cells (iPSCs) from somatic cells when used in combination with reprogramming factors; can replace Klf4.
溶解性
DMSO >25 mg/ml
穩(wěn)定性
2年 -20°C粉狀，6月-80°C溶于DMSO