更新時間:2024-11-17
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廠商性質(zhì):經(jīng)銷商
生產(chǎn)地址:
VU 0364439 1246086-78-1
VU-0364439
分子式:C18H13Cl2N3O3S 分子量:422.29
產(chǎn)品描述
VU 0364439是mGlu4正性變構(gòu)調(diào)節(jié)劑(PAM), EC50為19.8 nM。
靶點
mGluR4
IC50
19.8 nM
體外研究
體內(nèi)研究
VU 0364439 possess less than ideal PK properties preventing their use as in vivo tools. It shows better stability in HLM (63% remaining) than RLM (2% remaining).
溶解性
DMSO 85 mg/mL,水 <1 mg/mL,乙醇 <1 mg/mL
穩(wěn)定性
2年 -20°C粉狀,6月-80°C溶于DMSO
特征
VU 0364439 is the most potent mGlu4 PAM reported to date.